See also supplementary Policy issued on 10-06-97 and effective 10-15-97.

April 26, 1984

CHANCELLORS
LABORATORY DIRECTORS
MEMBERS, PRESIDENT'S CABINET

Dear Colleagues:

The attached policy on Disclosure of Financial Interest in Private Sponsors of Research supersedes the policy issued on April 8, 1982, and is effective immediately. The revised policy has been reviewed by many of you as well as the Academic Council, and it has received your endorsement. It has also been discussed with the Fair Political Practices Commission.

The revisions in this policy are a result both of our increased experience in this area, and of our continuing endeavor to refine and improve procedures. Most of the revisions to the policy are in Section IV, which gives additional guidance regarding the role of the Independent Substantive Review Committees.

Senior Vice President Frazer will issue the Guidelines for Disclosure and Review of Principal Investigator's Financial Interest in Private Sponsors of Research, which have also been revised, to implement this Policy.

Sincerely,

David Pierpont Gardner

Attachment

cc:
Principal Officers of The Regents
Senior Vice President Frazer
Chair, Academic Council Director Cole
Director Rogin

                                               University of California
                                                Office of the President
                                                         April 26, 1984


                    UNIVERSITY POLICY ON DISCLOSURE OF
            FINANCIAL INTEREST IN PRIVATE SPONSORS OF RESEARCH


I.    Policy on Disclosure of Financial Interest in Private Sponsors
      of Research

      A principal investigator must disclose whether or not he or
      she has a direct or indirect financial interest in the sponsor
      of research which is funded in whole or in part (a) through a
      contract or grant with a non-governmental entity or (b) by a
      gift from a non-governmental entity which is earmarked by the
      donor for a specific research project or a specific principal
      investigator.  Disclosure statements must be filed (a) before
      final acceptance of such a contract, grant, or gift; (b) when
      funding is renewed; and (c) within 90 days after expiration in
      the case of a contract or grant, or after funds have been
      completely expended in the case of a gift.  The Statements
      will be open to public inspection.  When disclosure indicates
      that a financial interest exists, an independent substantive
      review of the disclosure statement and the research project
      must take place prior to acceptance of the contract, grant, or
      gift.  Department chairs must disqualify themselves from
      approving a research proposal for a project which is funded in
      whole or in part by a non-governmental entity in which they
      have a financial interest.

      This policy is consistent with California Administrative Code,
      Title 2, Section 18705.


II.   Definitions

      A. "Financial Interest."  A "financial interest" in the
         sponsor of research means:

         1. A direct or indirect investment in the sponsor worth
            more than $1,000;

         2. A position as director, officer, partner, trustee,
            employee of or any other position of management in the
            sponsor;

         3. Income from the sponsor, including consulting income and
            gifts aggregating $250 or more in value, received by or
            promised to the principal investigator within 12 months
            prior to the time the award is made.  (For the purposes
            of this policy, "income" is further defined as in Gov.
            Code, Section 82030.)

      B. "Indirect Investment" or "Indirect Financial Interest."  A
         principal investigator has an "indirect investment" or
         "indirect financial interest" in a sponsor if:

         1. His or her spouse or dependent child has a financial
            interest in the sponsor;

         2. The principal investigator, his or her spouse, or
            dependent child own directly, indirectly, or
            beneficially a 10 percent interest or greater in any
            business entity or trust which has a financial interest
            in the sponsor of the research.

      C. "Equity (Ownership) Interest."  For the purposes of this
         policy, an "equity (ownership) interest" shall be an
         investment of more than $1,000 in the sponsor by the
         principal investigator, his or her spouse, or dependent
         children.


III.  Disclosure Requirement

      When a principal investigator has disclosed a financial
      interest in a sponsor of research, the required financial
      disclosure statement shall contain:

      A. Disclosure of Income

         1. The name and address of the sponsor and a general
            description of the business activity, if any, of the
            sponsor;

         2. A statement whether the aggregate value of income from
            the sponsor, or in the case of a loan, the highest
            amount owed to the sponsor, was at least $250 but did
            not exceed $1,000, whether it was in excess of $1,000
            but was not greater than $10,000, or whether it was
            greater than $10,000;

         3. In the case of a gift of $50 or more, a description of
            and the amount of the gift; and

         4. In the case of a loan, the annual interest rate and the
            security, if any, given for the loan.

      B. Disclosure of Equity or Ownership Interest and Disclosure
         of Position in Sponsor

         When an investment or equity (ownership) interest is
         required to be disclosed, or when the principal
         investigator is a director, officer, partner, trustee,
         employee, or holds any position of management, the
         disclosure statement shall contain:

         1. A general description of the business activity in which
            the sponsor is engaged;

         2. A statement whether the fair market value of the
            investment or interest exceeds $1,000 but does not
            exceed $10,000, whether it exceeds $10,000, but does not
            exceed $100,000, or whether it exceeds $100,000; and

         3. The position held in the entity by the principal
            investigator.


IV.   Independent Substantive Review Committees

      When disclosure indicates that a financial interest exists, an
      independent substantive review of the disclosure statement and
      research project shall take place before a contract, grant, or
      gift is accepted.  Chancellors, Laboratory Directors, and the
      Vice President--Agriculture and Natural Resources, after
      consultation with appropriate academic and administrative
      groups, shall develop a procedure for independent substantive
      review including the designation or establishment of a
      committee to conduct the review.

      The committees shall review disclosure statements and relevant
      features of the research project and on the basis of the
      review recommend to the Chancellor, Laboratory Director, or
      the Vice President--Agriculture and Natural Resources whether
      funding for the research project should be accepted and, if
      so, whether any modifications or conditions are needed.  The
      committees shall be sufficiently qualified through the
      experience of their members to promote respect for their
      advice.

      The committees should possess the academic, professional, and
      administrative competence and expertise necessary to review
      the subject matter of the proposed research and to assess the
      University and other public interests involved.  The committee
      may include graduate students and one or more qualified
      members not affiliated with the University.  The committee may
      consult with administrators, faculty, and others involved in
      the research and review process and the academic discipline in
      question.  It may also consult with or request principal
      investigators and department chairs to provide information in
      order to make a fully informed recommendation.  It may also
      invite individuals with competence in special areas to assist
      in the review process which require expertise beyond, or in
      addition to, that available to the committee.  The committee
      review should occur as early as possible in the overall review
      process to assure that commitments are not inadvertently made
      to the sponsors.  The committee shall, in its written
      documentation of the review, address each of the principles
      set forth in the Guidelines.  The basis for the recommendation
      should be clearly established in the documentation of the
      review.


V.    Implementation

      Chancellors, Laboratory Directors, and the Vice President--
      Agriculture and Natural Resources shall implement this policy. 
      They must provide the committees with appropriate
      administrative support, assure that technical advice on
      conflict of interest matters is provided, and assure that
      appropriate documents related to this policy are available to
      the public, as required by law.

      The Senior Vice President--Academic Affairs has responsibility
      for assuring compliance with applicable State law, this
      policy, and related University policies.  He is responsible
      for developing and issuing implementing guidelines for this
      policy.  He serves as the liaison on these matters with the
      Fair Political Practices Commission and with the campuses,
      Laboratories, and the Vice President--Agriculture and Natural
      Resources.  He consults with the Senior Vice President--
      Administration when financial reporting by principal
      investigators affects the Senior Vice President--
      Administration's Filing Officer responsibilities under the
      Political Reform Act.

April 27, 1984

CHANCELLORS
LABORATORY DIRECTORS
MEMBERS, PRESIDENT'S CABINET

Dear Colleagues:

I am pleased to issue the revised Guidelines for Disclosure and Review of Principal Investigators Financial Interest in Private Sponsors of Research. They supersede the Guidelines issued April 9, 1982, and are effective immediately. This document, along with the revised Policy (issued by President Gardner April 26, 1984), has been reviewed by many of you, as well as by the Academic Council. It has also been discussed with the Fair Political Practices Commission. This extensive review process has taught us a great deal about our accomplishments and the ways in which our efforts respond to the interests of the University and the public. The revised Policy and Guidelines build on our experience and should enable us to carry out our responsibilities even more effectively.

The most significant change in the Guidelines concerns the review process for statements which indicate the existence of a financial interest on the part of the principal investigator. This revision is in Section III which gives additional guidance on the role of the review committees. During our round of consultations, one observation we have made about this process concerns the importance of including sufficient information in the written summaries you provide to substantiate the review committee recommendations.

We will be continuing our consultations within the University on these matters and are planning to hold a meeting this spring with campus officials to discuss procedures and other related issues. We intend to hold such meetings on a regular basis to enable campuses to learn from each other's experiences and to assist in refining and improving our procedures.

I appreciate your continuing assistance in this matter.

Sincerely,

William R. Frazer

Attachment

cc:

Principal Officers of The Regents
Chair, Academic Council
Director Cole
Director Rogin


                                                    University of California
                                                    Office of the President
                                                             April 27, 1984


                   GUIDELINES FOR DISCLOSURE AND REVIEW 
              OF PRINCIPAL INVESTIGATOR'S FINANCIAL INTEREST 
                      IN PRIVATE SPONSORS OF RESEARCH


    These Guidelines implement the University Policy on Disclosure of
           Financial Interest in Private Sponsors of Research


I.       Rationale

         University research is currently reviewed according to the
         principles specified below and to other well-established
         policies guiding the conduct of sponsored research,
         including the principle that researchers must be free to
         pursue knowledge and that this freedom, which is essential
         to the research process, must not lightly be abridged.  The
         proposed review is supplemental to this process and takes
         advantage of the expertise and structure of the existing
         system.  While it is normally the case that a principal
         investigator takes responsibility for the central issues
         raised in these guidelines, when a principal investigator
         has a financial interest of the sort defined in the
         University Conflict of Interest Code regarding disclosure,
         it is possible that his or her judgment may appear to be
         affected by potential financial gain rather than by the
         pursuit of knowledge.  Therefore, it is proper that the
         principal investigator, the University community, and the
         public be assured that the principles central to the
         research process be followed.


II.      Principles

         A. Traditional conflict of interest situations should
            continue to be avoided

            In the conventional sense, conflict of interest refers
            to situations in which employees may have the
            opportunity to influence the University's business
            decisions in ways that could lead to personal gain or
            give advantage to associates or firms in which employees
            have an interest.  Principal investigators, like all UC
            employees, are expected to continue to separate their
            University and private interests in accordance with
            existing University policies and State law.

         B. Research is appropriate to the University

            The research must be appropriate to the mission of the
            University, i.e., promising significant contributions to
            scholarship and knowledge and, when possible, providing
            appropriate opportunities for students.  The suitability
            of the research would be judged according to the
            standards of the discipline and should be guided by the
            principles and policies of Regulation 4, Special
            Services to Individuals and Organizations.

         C. The teaching and research environment is open

            The teaching and research environment should continue to
            promote the free exchange of ideas, information, and
            materials among students and faculty in all of their
            forums--classrooms, laboratories, meetings, and anywhere
            in the University.  Selection of students for
            participation in the research project should not be
            inappropriately influenced by the interest of the
            sponsoring firm.

         D. Freedom to publish and to disseminate research results
            is preserved

            Consistent with current University policies, there
            should be no limits placed on the freedom to publish,
            except for short periods of delay that permit a sponsor
            to comment or to permit filing of patent applications.

         E. Licensing agreements require thorough review

            If the principal investigator has a financial interest
            in the sponsoring firm, justification for granting of an
            exclusive license to the sponsoring firm will require
            careful review to ensure that the best interests of the
            public and the University are served.  This review
            should be coordinated with the Patent Administrator for
            consideration in negotiations concerning patent rights.

         F. University facilities and resources are used
            appropriately

            As is currently the policy, University resources--
            supplies, equipment, and facilities, as well as staff
            time--must not be used for the benefit of the firm
            without proper compensation.

III.     Procedures for conduct of committee review

         Review committees should be guided by the following
         practices and apply them as appropriate.

         A. Assure adherence to relevant University policies,
            guidelines, and regulations

            These policies are identified; summarized, and
            paraphrased in the Compendium of Specialized University
            Policies, Guidelines, and Regulations Related to
            Conflict of Interest issued on June 23, 1982 and revised
            on August 11, 1982.

         B. Consider, to the extent possible, the nature and extent
            of the financial interest in the relationship of the
            principal investigator to the sponsoring entity

            In addition, to the extent possible, the potential
            financial effects of the research both on the sponsor
            and on the principal investigator should be considered.

         C. Give special consideration to:

            1. Conditions of research agreements which involve:

               a. The testing of a sponsor's products or inventions

               b. Research conducted in the sponsor's facilities

               c. Research performed jointly with someone from the
                  sponsor

               d. Research involving the provision of proprietary
                  information from the sponsor.

            2. The relationship between the principal investigator
               and the sponsor when the principal investigator has:

               a. A significant ownership interest in the sponsor

               b. The opportunity to receive substantial financial
                  benefits from the sponsor (e.g. bonuses, stock
                  options)

               c. A long term or ongoing consulting relationship
                  with the sponsor.

         D. Obtain additional information from the Principal
            Investigator when necessary

            Since committees may find it useful to get more
            information from the principal investigator than is
            covered in the financial disclosure statement, a sample
            form is provided (entitled the Principal Investigator's
            Addendum to Statement of Economic Interest) which
            includes possible questions and also advice to the
            principal investigator about the purpose of the request
            and its legal status.

            In the event that such a sample form, or the like, is
            utilized, it must contain a privacy statement.

         E. Apply the principles set forth in II above:

            Some questions which might be considered when
            appropriate are:

            1. Do the facts and circumstances suggest that the
               principal investigator's financial involvement with
               the sponsoring organization will in any way affect or
               impair the conduct of the research in accordance with
               the applicable University policies and the highest
               professional standards?

            2. How will the interests of the University be
               maintained in consideration of the principal
               investigator's interest in the sponsor?

            3. Will the research project lead to the advancement of
               knowledge rather than to routine testing of primary
               benefit to the sponsor?

            4. How will this research project contribute to the
               University's mission of teaching, research, and
               public service?

            5. Do the potential public benefits to be gained from
               undertaking this research outweigh any potential
               erosion of academic freedom, collegiality, or public
               trust?

            6. Are the best interests of the University and the
               public served by granting an exclusive license to the
               sponsor?

         F. Make a Recommendation Providing the Necessary
            Documentation and Indicating:

            o  Acceptance of the gift or grant.

            o  Non-acceptance of the gift or grant.

            o  Modification, specifying what modifications need to
               be made, or what conditions need to be imposed.


Attachment to Guidelines Sample Form PRINCIPAL INVESTIGATOR'S ADDENDUM TO STATEMENT OF ECONOMIC INTEREST Campus Principal Investigator _________________________________________ NAME DATE Research Project ____________________________________________ Proposed Sponsor ___________________________________________ Introduction (Include here information about the research process on the campus for review of disclosures of financial interest; reasons additional information is needed; and any other relevant information.) Request for Information (recommended questions) 1. Describe the nature of your financial interest in the sponsor, such as your responsibilities as a director, officer, partner, trustee, employee, consultant, ownership interest including actual or promised options or convertible securities or loans, and the relationship between that interest or position and this research project. Please indicate if there are any written agreements between you and the sponsor. 2. Describe to the extent possible the potential financial effect of this project on the sponsor. 3. Explain if you separately, or along with your spouse and dependent children, own 10% or more of the entity sponsoring this research project. 4. Describe your role in the research program of the sponsoring entity. 5. Describe in some detail if the research project involves: a. testing b. licensing or other approval of any product or device by a governmental agency; or c. development of any product or other device of potential economic value to the sponsor; 6. Explain how the research will lead to the extension of knowledge, to an increased effectiveness in teaching, or will provide a public service. 7. Provide funding information about the project: a. Is the sponsor funding the full cost of the project? b. If other funding sources are involved in this research project, please indicate who they are and the dollar value of their support. c. Will the University be contributing to this project, either by supporting faculty or other salaries, or by directly providing supplies, equipment, or facilities? 8. Describe any participation of the sponsor in deciding the direction of the research, once begun. 9. Describe the role of students in the research project. 10. Indicate whether selection of topics for students will be restricted by commercial considerations. 11. Describe how the terms of your relationship with the sponsor could affect the free exchange of ideas, information, and materials among students and faculty. 12. Describe how the terms of your relationship with the sponsor could affect publication or other dissemination of research results by faculty or students involved in the project. 13. Indicate whether the contract, grant, or gift funding this research will require the granting of an exclusive license to the sponsor. 14. Indicate whether the sponsor will be providing any proprietary data for use on the project. 15. Indicate whether possession of proprietary data will require controls on access to the research data. Please describe any such requirements. (Please include any additional information that may be of use to the committee in reviewing the proposal, including any background documentation about the development of the project, related research interests, negotiations or other correspondence with the sponsor, and a proposed budget if one has not already been submitted.) ________________________________________ SIGNATURE ________________________________________ DATE
Privacy Statement* The State of California Information Practices Act of 1977 (effective July 1, 1978) requires the University to provide the following information to individuals who are asked to supply information about themselves: The principal purpose for requesting the above information is to accomplish the independent and substantive review of positive financial disclosures as required by the Policy on Disclosure of Financial Interest in Private Sponsors of Research (Revised March 1984). University policy and State law authorize maintenance of this information. Submission of this information is mandatory. The consequences of not providing all or any part of the requested information could be nonacceptance of your award from the proposed sponsor. The information is a public record under University policy and State law. Individuals have the right to review their own records in accordance with Academic Personnel Manual, Section 160. Information about this records policy may be obtained from the campus or Office of the President--Office of Academic Affairs. The officials responsible for maintaining the information collected on this form are the (appropriate campus officer) and the Senior Vice President--Academic Affairs. * This statement must be included in the form.