FUNDED RESEARCH

The 78 research projects funded in cycle I are outlined in the sections that follow. An introduction to each section describes the Council's objectives in choosing the respective area for funding, and explains how the funded research fits the Program priorities. The abstracts for the funded research in that area follows; each abstract is headed with the project's title and the principal investigator's name and institution. The duration and cost of each project are listed in the Summary of Awards by Institution.

ETIOLOGY ABSTRACTS

Two Candidate Breast Cancer Genes on Chromosome 17
John Groffen, Ph.D.
Childrens Hospital of Los Angeles

Metabolism of Environmental Chemicals as Breast Cancer Risk
Regine Goth-Goldstein, Ph.D.
Lawerence Berkeley National Laboratory

Xenoestrogens andGenetic Damage in Breast Cancer
Moire Robertson Creek, Ph.D.
Stanford Research Institute International

Physical Activity: Impact on Hormones and Breast Cancer Risk
Catherine L. Carpenter, Ph.D.
University of Southern California

Susceptibility to Breast Cancer: Dietary and Other Factors
Ralph J. Delfino, M.D., Ph.D.
University of California, Irvine

Alcohol and Risk of Estrogen-Receptor Positive Breast Cancer
Shelley M. Enger, Ph.D.
University of Southern California

Genetic Susceptibility to Breast Cancer
Brian E. Henderson, M.D.
University of Southern California

Vitamin D & Genetics of Vitamin D Receptor in Breast Cancer
Sue A. Ingles, Ph.D.
University of Southern California

Case-Control Study of Breast Cancer in Asian-American Women
Anna H.Wu, Ph.D.
University of Southern California

 

PATHOGENESIS ABSTRACTS

The Invasive Nature of Epithelial Breast Cancer Cells
Pierre-Yves Desprez, Ph.D.
Lawrence Berkeley National Laboratory

BAX Gene Expression in Breast Cancer
John Reed, Ph.D.
La Jolla Cancer Research Foundation

Growth Factor Control of Breast Tumor Cell Proliferation
Richard C. Kurten, Ph.D.
University of California, San Diego

ErbB2 and Control of Growth in Breast Cancer Cells
Deborah L. Cadena, Ph.D.
University of California, San Diego

Mechanisms of Aberrant Cell Growth in Breast Cancer
Daniel J. Donoghue, Ph.D.
University of California, San Diego

Regulatory Mechanisms for Growth & Motility in Breast Cancer
Ulla G. Knaus, Ph.D.
The Scripps Research Institute

The Role of MAR-Binding Protein in Breast Cancer
Terumi Kohwi-Shigematsu, Ph.D.
La Jolla Cancer Research Center

Loss of P53 Tumor Suppressor Function in Breast Cancer
Jamil Momand, Ph.D.
City of Hope National Medical Center

Biology of Telomere Length Conservation in Breast Cancer
Darryl K. Shibata, M.D.
University of Southern California

New Method for Measuring Breast Cancer Gene Expression
Daniel Pinkel, Ph.D.
Lawrence Berkeley National Laboratory

Genes Which Cause Increased Cellular DNA in Breast Cancer
Michael F. Press, M.D., Ph.D.
University of Southern California

A Candidate Breast Tumor Suppressor Gene on Chromosome 13
David R. Schott, Ph.D.
California Pacific Medical Center

Genes Involved in Multistep Mammary Tumorigenesis
Greg M. Shackleford, Ph.D.
Childrens Hospital, Los Angeles

Malignant Transformationin Breast Epithelium
Heinz Furthmayr, M.D.
Stanford University

Role of L-Plastin in Breast Cancer
Ching-Shwun Lin, Ph.D.
University of California, San Francisco

Cell Microenvironment and Progression of Breast Cancer
Andre Lochter, Ph.D.
Lawrence Berkeley National Laboratory

Breast Cancer Progression and the Extracellular Matrix
Francis S. Markland, Jr., Ph.D.
University of Southern California

Model of Human Breast Cancer Development and Progression
Satyabrata Nandi, Ph.D.
University of California, Berkeley

HSP27 Regulation of Breast Tumor Blood Vessel Growth
Randolph S. Piotrowicz, Ph.D.
The Scripps Research Institute

Changes in Transport into the Nucleus in Breast Cancer
Deborah J.Sweet, Ph.D.
The Scripps Research Institute

Control of Estrogen Production in Breast Cancer
Shiuan Chen, Ph.D.
Beckman Research Institute of the City of Hope

Isolation of Estrogen Receptor Cofactors from Breast Tumors
Thorsten Heinzel, Ph.D.
University of California, San Diego

Role of Estrogen in the Origin of Breast Cancer
Peter J. Kushner, Ph.D.
University of California, San Francisco

New Endocrine Strategy to Prevent Breast Cancer Progression
Richard J. Pietras, M.D., Ph.D.
University of California, Los Angeles

Progesterone Action in Human Breast Cancer
G. Shyamala, Ph.D.
Lawrence Berkeley National Laboratory

Understanding Tamoxifen A Drug for Breast Cancer
Paul Webb, Ph.D.
University of California, San Francisco

PREVENTION ABSTRACTS

Growth Inhibition of Breast Cancer Cells by Interferons
Ke Shuai, Ph.D.
University of California, Los Angeles

Prevention of Breast Cancer by Blocking Integrin Function
Jeffrey W. Smith, Ph.D.
La Jolla Cancer Research Foundation

EGFR Structure for Drug Design Targeted to Breast Cancer
Chung-leung Chan, Ph.D.
University of California, San Diego

Regaining Control over Breast Cancer Cells
Michael Karin, Ph.D.
University of California, San Diego

Estrogen Receptor Regulation in Breast Cancer
Lisa A. McPherson, Ph.D.
Stanford University

Vitamin D and Breast Cancer Prevention: Cell Death vs Growth
Valerie M. Weaver, Ph.D.
Lawrence Berkeley National Laboratory

The Breast Tumor Suppressor Function of Hyaluronidase
Robert Stern, M.D.
University of California, San Francisco

Breast Cancer Chemoprevention by Vitamin D Plus Retinoids
Marcia I. Dawson, Ph.D.
Stanford Research Institute International

Prevention of Breast Cancer Tumor Growth by Retinoic Acid
Yi Liu, Ph.D.
La Jolla Cancer Research Foundation

A Peptide Vaccine for Breast Cancer Prevention
Esteban Celis, M.D., Ph.D.
Cytel Corporation

Molecular Design for Prevention of Breast Cancer Progression
Joseph R. Couto, Ph.D.
Cancer Research Fund of Contra Costa

Peptide Vaccines for Immunoprevention of Breast Cancer
Thomas J. Kipps, M.D., Ph.D.
University of California, San Diego

Blocking Breast Cancer Progression with Radioactive Antibody
Michael Samoszuk, M.D.
University of California, Irvine

The Role of Plant Estrogens in Reducing Breast Cancer Risk
Pamela L. Horn-Ross, Ph.D.
Northern California Cancer Center

Determinants of Breast-Conserving Surgery and Survival
Cyllene R. Morris, D.V.M., M.P.V.M., Ph.D.
California Public Health Foundation

Exercise, Ovarian Function, and Breast Cancer Prevention
Lisa S. Shames, Ph.D.
University of Southern California

Alteration of Dietary Fat to Reduce Breast Cancer Metastasis
Kent L. Erickson, Ph.D.
University of California, Davis

Does Change in Emotional Expression Mediate Cancer Survival?
Janine E. Giese-Davis, Ph.D.
Stanford University

Breast Cancer Chemotherapy: Does It Impair Brain Function?
Mary H. Wieneke, Ph.D., M.S.
California School of Professional Psychology

 

EARLY DETECTIONBABSTRACTS

Platelet Factor 4: A Marker for Malignant Breast Tumors
Per Borgstrom, Ph.D.
La Jolla Institute for Experimental Medicine

MRI Detection of Micro-vascular Status in Breast Cancer
Robert C. Brasch, M.D.
University of California, San Francisco

Telomerase: A Factor for Early Detection of Breast Cancer
Nam Woo Kim, Ph.D.
Geron Corporation

Investigation of Improved Drug Delivery in Breast Cancer
Orhan Nalcioglu, Ph.D.
University of California, Irvine

Cripto: A Breast Cancer Marker?
Christina C. Niemeyer, Ph.D.
La Jolla Cancer Research Foundation

Breast Cancer Incidence in Women With Abnormal Cytology
Margaret R. Wrensch, Ph.D.
University of California, San Francisco

Hybrid Grid Detector for Early Detection of Breast Cancer
John M. Boone, Ph.D.
University of California, Davis

Noninvasive Measurement of Blood Flow Through Breast Tumors
Michael H. Buonocore, M.D., Ph.D.
University of California, Davis

A Non-Invasive Method of Locating Malignant Breast Tumors
Edward J. Hoffman, Ph.D.
University of California, Los Angeles

Real Time Telemanagement of Mammography Examinations
H. K. Huang, D.Sc.
University of California, San Francisco

Breast Imaging with an Ultrasound CT Scanner
George R. Leopold, M.D.
University of California, San Diego

Novel PET Cameras for Earlier Detection of Breast Cancer
William W. Moses, Ph.D.
Lawrence Berkeley National Laboratory

New Imaging Modality For Early Detection of Breast Cancer
William M. Pardridge, M.D.
University of California, Los Angeles

Electronic Imaging for Hospital and Community-Based Mammography
Daniel J.Valentino, Ph.D.
University of California, Los Angeles

USC/Norris Breast Cancer Research Training Program
Ronald K. Ross. M.D.
University of Southern Calitornia

IMPROVED ACCESS ABSTRACTS

Benign Breast Disease, Biopsy and Cancer Preventive Self-Care
Jacqueline O'Connor, Ph.D.
University of California, Davis

Group Intervention For Women at High Risk for Breast Cancer
David K. Wellisch, Ph.D.
University of California, Los Angeles

Effects of Stress and Support on Delay in Cancer Treatment
Karyn L. Angell, Ph.D.
Stanford University

Race/Ethnicity and Late Stage Breast Cancer
David J. Delgado, Ph.D., M.P.H.
University of Southern California

False-Positive Mammograms: A Barrier to Annual Screening?
Phillip Gardiner, Dr.P.H.
Northern California Cancer Center

Impact of Physician Attitudes on Mammography Screening Rates
Miriam Komaromy, M.D.
University of California, San Francisco

Understanding Breast Cancer Screening in Filipino Women
Annette E. Maxwell, Dr. P.H.
University of California, Los Angeles

Promoting Early Detection of Breast Cancer Among Vietnamese
Stephen J. McPhee, M.D.
University of California, San Francisco

How Women Decide to Seek Evaluation of Breast Symptoms
Noreen Facione, Ph.D.
University of California, San Francisco