Program 781,
  April 15, 2003

 

A. Neuroscientists Identify Distinct Molecular Key to Overcoming Fear

Narrator: This is Science Today. Neuroscientists at UCLA have discovered a distinct molecular process in the brain that's involved in overcoming fear. Dr. Mark Barad, who led the research, says they studied a model for the kind of psychotherapy famously used in animals by Pavlov, called extinction of conditional fear.

Barad: We're trying to understand what the molecular mechanisms of extinction are so that we can devise medications that will make extinction go faster and if we can do that, we believe that we'll be able to make psychotherapy go faster, because one of the problems with psychotherapy is that it takes a long time.

Narrator:The researchers discovered a molecular channel in brain cells that's required to overcome fear, but plays no part in becoming fearful or expressing fear. This may have a huge impact on treating anxiety disorders.

Barad: This would not reduce people's fear and it wouldn't impair their ability to learn new associations about dangerous things. Instead, you would be able to specifically get rid of a fear that you think was no longer adaptive, no longer appropriate.

Narrator: For Science Today, I'm Larissa Branin.

B. How the Roundworm Offers Insight into the Human Brain

Narrator: This is Science Today. Researchers at the University of California, San Francisco, are making major breakthroughs in understanding the formation of the nervous system by looking to the roundworm. Lead investigator Cori Bargmann says the nerve connection in a developing roundworm offers insight into understanding the trillions of connections in the human brain.

Bargmann: So the way that I think about why we would work on a worm instead of working on the human brain is for the same reason that if you were trying to understand how an engine worked, you'd be better off studying the 1964 Volkswagen Beetle than a brand new Boeing 777 aircraft. And the analogy here is that we want to understand the simple animal-the Volkswagen-the worm. And that then we can use the insights we learn from that to target our questions to understanding the human brain in a much more precise and intelligent way.

Narrator: Using a fluorescent imaging technique to see the brain cell interactions of the worm, Bargmann and her team have been able to identify a molecule that's crucial to making nerve connections in the brain. For Science Today, I'm Larissa Branin.

C. Dramatic Rise of Diabetes Among Latino Immigrant Population

Narrator: This is Science Today. In the last decade, there's been about a fifty percent increase in diabetes among the immigrant Latino population in California. According to a two-year study of Latina women led by Marc Schenker, a preventive medicine professor at the University of California, Davis, the evidence is clear that eating low quality foods, loaded with fat and sugar, are having a major impact on Latino health.

Schenker: Obesity is an increasing problem among Latino immigrants to California, even in some situations such as farm workers, where you would think obesity would not be a problem, and yet it's becoming one.

Narrator: This is in part due to a cultural change in traditional diets.

Schenker: When we looked at factors such as fast food intake, traditional food intake, fruit and vegetable intake, what we saw was that the profile was worse among women born in the U.S. or who had immigrated here, compared to those who were born in Mexico.

Narrator: For Science Today, I'm Larissa Branin.

D. Measuring and Understanding Environmental Factors that Affect Kids

Narrator: This is Science Today. It's only been in the last ten years or so that policy makers began to focus more on how various environmental factors and conditions particularly affect children and not just adults. In this spirit, environmental health researcher Amy Kyle of the University of California, Berkeley, collaborated with the Environmental Protection Agency to lay out the types of environmental factors that are most important to children.

Kyle: We find that while lead in blood in children has gone down overall, we still have a significant number of children who are still at risk from lead and we really need to do something about that.

Narrator: Kyle's study also found that 8% of women in this country of childbearing age have higher than normal levels of mercury in their blood and this affects babies in the womb.

Kyle: They're at greatest risk while their brains are still developing. We also have learned that mercury levels in the blood that the developing child is exposed to are actually a little bit higher than the mothers. So it is a significant concern. We need to think about where that mercury is coming from and see where it is coming from and see what we can do about that.

Narrator: For Science Today, I'm Larissa Branin.

E. Privacy Protection Issues and Wireless Microsensor Technology

Narrator: This is Science Today. Researchers developing wireless mircosensory networks at the University of California, Berkeley, are making giant leaps in our capability to monitor everything from individual molecules to massive security systems. As the application base widens, David Culler, a chief innovator of this technology, says that privacy protection is a large consideration in their proceedings.

Culler: Very deep social issues associated with this technology. It's wonderful that you could monitor-get lots of information about your self or people that you care about. But now you have to ask, how is that information controlled? Who has what rights to it, how is it processed, how is it maintained? And much of that needs to be sorted out.

Narrator: Currently there are about 150 research groups around the world using the Berkeley platform as a basis for sensory network research.

Culler: And again, I think it's very important that the research community is asking those questions and tries to get a good handle on that while the technology is still at a young stage. So privacy and security are a big part of the agenda moving forward.

Narrator: For Science Today, I'm Larissa Branin.

 

 

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