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A.
First Molecule Discovered that Directs Neuron Synapses
Narrator:
This is Science Today. Researchers at the University
of California, San Francisco, have discovered a
'matchmaking' molecule that directs neurons to form
connections with each other during an animal's early
development. Neuroscientist Cori Bargmann, who led
the study, says this connection creates synapses
that are essential to all behavior.
Bargmann:
It's important both for understanding normal development
and normal function of the brain and for studying
many brain disease states, where the right connections
don't form or wrong connections form abnormally.
Narrator:
Since the matchmaker protein discovered is related
to proteins in humans, it may someday help in the
treatment of chronic epilepsy or chronic pain, in
which neurons form the wrong connections and cause
synapse formation to go awry.
Bargmann:
When
the two nerve cells don't make the right connection,
they make a bunch of wrong connections. The nerve
cell gets desperate and starts connecting up with
anything that's in its environment. So if the role
of the matchmaker is to get the right cells together,
if the matchmaker is absent the nerve cell goes
to a bar and hooks up with all kinds of wrong partners.
Narrator:
For Science Today, I'm Larissa Branin.
B.
Functional MRIs May Benefit from Vision Science Research
Narrator:
This is Science Today. New findings by vision scientists
at the University of California, Berkeley, may significantly
improve the resolution of brain scans from functional
magnetic resonance imaging, or fMRI. Jeffrey Thompson,
a vision science graduate student who led the study,
says fMRI's generally focus on an increase in blood
flow in various parts of the brain on a relatively
large scale.
Thompson:
So what we did was we measured oxygen levels in the
tissue in a very localized spot in the brain and also
the same time, we were able to measure the actual
neural activity that's going on in that area.
Narrator:
The
researchers found that an initial dip in oxygen levels
at a micrometer scale is an earlier, more precise
signal of nerve cell activity than the current measure
of blood flow on a millimeter scale.
Thompson:
What we hope it implies is that if we zero in on this
initial dip in oxygen with the fMRI, that we could
basically increase the spatial resolution of fMRI,
which would have implications for examining neural
circuits at a much finer scale than what we are currently
able to do.
Narrator: For
Science Today, I'm Larissa Branin.
C.
Advances in Brain Tumor Surgery
Narrator:
This is Science Today. There are two crucial elements
to successful brain tumor surgery - the removal of
the tumor and causing no harm to critical areas of
the brain. Dr. Neil Martin, chief of the UCLA Neurosurgery
Division, says in the past, it was difficult for surgeons
to visually see the margin of the tumor.
Martin:
We now have an operating room with an MRI scanner
in it. So we remove the tumor, simply pivot the patient,
get a scan and if there's anything left we take it
out immediately. It's really made a major difference
in the success of removing tumors of this sort.
Narrator:
To ensure no damage is done, patients can even be
operating on while awake.
Martin:
Surprisingly, you can numb the pain sensitive structures
in the scalp and the head and operate on the brain
without the patient experiencing any discomfort and
that allows us to test them, to ask them to speak,
to read, identify objects while we're actually working
to make sure that those critical language functions
are preserved and that none of those are injured as
the tumor's removed.
Narrator:
For Science Today, I'm Larissa Branin.
D.
How Microsensors May Change Farm Life
Narrator:
This is Science Today. Researchers at the University
of California, Berkeley, are developing the cutting-edge
of agri-business-a technology of networked microchip
sensors that can closely monitors farms. David Culler,
a professor of computer science and an expert in this
technology, explains how wireless microsensors may
dramatically change life on the farm.
Culler:
That same notion of monitoring, or dense monitoring
of space, if you take it out to the farm, that's what
agri-business-you can imagine precision agriculture,
where you really would like to control how you're
watering, how you're fertilizing in response to the
actual soil moisture, how it drains, the sun, the
wind, that kind of thing.
Narrator:
Culler says that by strategically placing microsensors
on their farm, growers can get an enhanced picture
of the physical changes and activities that occur
across space and time.
Culler:
If you think about agri-business, there's this whole
flow of different kind of input: seeds, fertilizer,
soils, water, so forth. You want to know where they
are all coming from. How do they then get distributed
to the places they are needed? Are the crates where
the berries are being picked? How do all the pieces
come together at the right time?
Narrator:
For
Science Today, I'm Larissa Branin.
E.
A New Test Targets Various Sources of Lead Exposure
in Children
Narrator:
This is Science Today. A new technique that detects
the chemical "fingerprints" of different
sources of lead exposure may help researchers zero
in on the causes of childhood lead poisoning, which
is typically hard to do. Donald Smith, a professor
of environmental toxicology at the University of California,
Santa Cruz, tested the technique and says even though
the United States has greatly reduced the major sources
of lead, a large number of children still suffer from
lead poisoning.
Smith:
Because we've used lead for so long in a number of
different industrial materials, including as an additive
in gasoline. As a result of all those industrial activities
and the use of lead as combustion in cars, there's
enormous amounts of lead, essentially stockpiled in
the dust and soil of urban areas.
Narrator:
Another major source of lead exposure in children
is lead-based paints in old, deteriorating housing.
Smith:
The most
prudent thing that parents can do to help reduce that
potential exposure is just to be aware of how the
children may be exposed and how they can, by keeping
their environment clean - whether it be the household
or the outside environment - how they can actually
reduce the intake of lead to the child.
Narrator:
For Science Today, I'm Larissa Branin.
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