Program 748,
  August 27, 2002

 

A. A Revolutionary Artificial Back Disc Under Study

Narrator: This is Science Today. Orthopedic surgeons at the University of California, San Francisco are joining 13 other centers in a four-year study to determine the safety and effectiveness of a European-designed implant called the Prosdisc that may replace damaged lower back discs. Dr. David Bradford of UCSF says the Prosdisc shows lot of promise.

Bradford: Over 300 to 400 cases now have been done worldwide and over 100 cases have been done in North America and the data looks very good - the early results. Nonetheless, the FDA wants to see controlled studies comparing this with standard fusion to see if truly this result is better than what you might see with a fusion.

Narrator: The ball-and-socket design of Prosdisc allows normal functioning and structure of the spine.

Bradford: We've done this procedure already here at UCSF. We feel that the results are most likely to show that this would be approved as a stand-alone device.

Narrator: For Science Today, I'm Larissa Branin.

B. An Innovative Drilling Technique Has Potential Use on Mars

Narrator: This is Science Today. Innovative drilling instruments and techniques developed to probe subglacial lakes in Antarctica, may someday lead to similar work on Mars. In fact, cosmic ray physicist Buford Price, of the University of California, Berkeley says their sterile, ultraviolet light-emitting detectors could possibly be used to search for signs of life on Martian polar caps.

Price: We know that there exists water widely distributed over both the north and South Pole on Mars. Whether it's in the form of liquid or solid, almost certainly most of it, at least down to many meters depth, is frozen. But that temperature is definitely such that certain kinds of organisms can survive.

Narrator: These microorganisms are aptly called extremophiles.

Price: Some of them don't need oxygen, some don't need sunlight, some eat hydrogen and breathe methane - they really are weird! They are so unusual that it has encouraged those biologists who are interested in life on other planets.

Narrator: For Science Today, I'm Larissa Branin.

C. Why Farm Children Have Less Asthma

Narrator: This is Science Today. Images of growing up on a farm are often associated with robust health - and now there's scientific evidence supporting this old association. Preventive medicine specialist, Mark Schenker, of the University of California, Davis, says studies have shown that children who grew up on a farm are less likely to suffer from allergies and asthma, thanks to exposure to allergens, or antigens, found on the farm.

Schenker: Exposure to a number of antigens that exist on the farm protects against subsequent development of allergies and probably asthma.

Narrator: Schenker says this so-called 'hygienic hypothesis' may also explain why children in urban environments have higher rates of allergies and asthma.

Schenker: As we move to more hygienic environments without exposure to a number of antigens in early life, we make ourselves at increased risk for allergic, asthmatic reactions as adults.

Narrator: For Science Today, I'm Larissa Branin.

D. Researchers Creating an Efficient, MEMS-based Fuel Cell

Narrator: This is Science Today. Micro-electrical-mechanical systems, or MEMS, use chemical or other types of processes to literally micro machine silicon into mechanical structures. An actual systems-on-a-chip concept. Jeff Morse, a researcher at the Lawrence Livermore National Laboratory, is working on a MEMS-based fuel cell power source, which he says may one day replace rechargeable batteries.

Morse: This is in fact a miniature fuel cell and what fuel cells offer is they nominally will operate off of either hydrogen fuel, or I think more recently for small and portable applications, hydrocarbon-based fuels - for example, methanol or butane.

Narrator: The benefit of this technology is that it's a direct-conversion device.

Morse: The key thing is it's storing the energy as fuel and so it converts that directly to electricity with a little bit of losses due to heat and inefficiencies, but by comparison to batteries, you might see maybe a factor of two or three - and possibly even factors of ten improvements in operating time.

Narrator: For Science Today, I'm Larissa Branin.

E. Exposure to Pesticide Interferes with Frog Sexual Development

Narrator: This is Science Today. A recent study has found that frogs exposed to a common pesticide called atrazine have problems with the development of their sexual characteristics. Biologist Tyrone Hayes of the University of California, Berkeley says some of the testosterone was converted to estrogen.

Hayes: The conversion of testosterone to estrogen results in a drop in the masculinizing hormone, so that animals don't develop some of their masculine features if they're male. But in addition, they're also feminized. The production of estrogen by the male frogs causes development of female characters that don't normally appear in males.

Narrator: Although the effects of these changes on frog fertility are not yet known, Hayes says his results could have implications for human health.

Hayes: The genes that control sex and gonadal differentiation in humans, those same genes are present in amphibians. Some of the sequences are exactly the same. Male frogs croak and females don't. In humans, males have deeper voices than females for the same reasons.

Narrator: For Science Today, I'm Larissa Branin.

 

 

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