Program 740,
  July 2, 2002

 

A. A Robotic Microscope Helps Scientists Track Cells Over Time

Narrator: This is Science Today. A new robotic microscope is helping researchers track cells over time - and without all the tedious counting and analyzing. Dr. Steven Finkbeiner, a researcher at the University of California, San Francisco's Gladstone Institute of Neurological Disease, invented the robotic microscope.

Finkbeiner: The microscope can do what it took us six to eight weeks to do in about twelve minutes now…so that's one major advantage, is that it's faster and no one has to sit there for eight hours day after day, doing some of these counting measurements.

Narrator: Equipped with fast and precise motors - the microscope can zero in on and photograph specific cellular reference points, as the images automatically appear on a computer screen for analysis. Finkbeiner is currently using this technology to study neurons in Huntington's Disease.

Finkbeiner: The remarkable thing is now we can follow these little individual neurons through time and that enables us to figure out what things change first in neurons that lead to a particular outcome, so we can begin to understand what factors are actually prognostic.

Narrator: For Science Today, I'm Larissa Branin.

B. Why are there Regional Differences in U.S Wildfires?

Narrator:This is Science Today. So far, this year alone wildfires have burned almost two million acres. That's twice the ten-year average for this point in the year. Major fires have struck all parts of the country, from New Jersey and Florida to Colorado and California. But all regions are not equal when it comes to fire danger. Fire Scientist Scott Stephens of the University of California, Berkeley, says the severity of wildfires in different parts of the United States has changed in recent decades.

Stephens: Most of the West increased in the amount of acres that've burned in the last 60 years. Some places actually in the Northeast and the Eastern U.S., and also the Southeast, have actually seen decreases.

Narrator: Stephens says natural causes, like lightning, account for some of these differences. But there are also other reasons.

Stephens: You know I think one of the real changes is really the cultures of the people. The Southeast United States has really come up with a culture of fire and people together. A lot of people use fire down there culturally for their practices and their management.

Narrator: Whereas in the West, there's less use of fire as a preventive tool. For Science Today, I'm Larissa Branin.

C. Childhood Leukemia Mutation Displays a Long Latency Period

Narrator: This is Science Today. A new study has shown that a genetic mutation associated with a type of childhood leukemia commonly occurs before birth, but can lay dormant for up to twelve years. Lead researcher Joseph Wiemels of the University of California, San Francisco, says the long latency period of the genetic mutation, called a translocation, has implications for adults.

Wiemels: The translocation is occurring in a very early precursor blood cell, a cell that's going to hang around for twelve years and maybe, potentially for a lifetime. And perhaps even some adult leukemias with this translocation may have carried that translocation from the time of birth.

Narrator: The research also suggests that a second event after the prenatal, long latency period must occur to cause leukemia.

Wiemels: But maybe someday we could predict for leukemia and perhaps have some intervention to prevent the disease from getting the second event and becoming a full-blown disease.

Narrator: For Science Today, I'm Larissa Branin.

D. Why Europeans Smoke More than Americans

Narrator:This is Science Today. A recent worldwide study of smokers and non-smokers in fourteen countries, has found that on average, Europeans smoke a lot more than Americans. Preventive medicine specialist, Stephen McCurdy, of the University of California, Davis helped conduct the large-scale study and says in Spain for example, men lit up more than half as much as their American counterparts.

McCurdy: The study confirmed what many of us have noted just in our daily experience who have been to Europe, and that is that smoking is much more common in Europe than it is in the United States.

Narrator: But why do Spaniards and other Europeans smoke more? McCurdy says it's a matter of economics.

McCurdy: If you look back twenty and thirty years ago, economically most people did not have the financial means to smoke. But now with their entry into the European union and the rapidly advancing improvement in economic circumstances, people have the money and the ability to smoke…and certainly many have done that.

Narrator: For Science Today, I'm Larissa Branin.

E. A Study Finds We're a Sleep Deprived Nation

Narrator: This is Science Today. According to the National Sleep Foundation, almost two-thirds of Americans are sleep deprived. And yet, Dr. Chris Gillin, of the University of California, San Diego conducted studies suggesting the brain may have an adaptive resource to make up for sleep deprivation. Still, Gillin says a lack of sleep should not be taken lightly.

Gillin: Performance drops when people are sleep deprived. They're at increased risk of automobile accidents and it certainly has been implicated in some very serious disasters. For example, the Three Mile Island nuclear disaster occurred in the middle of the night and it was thought that sleep deprived employees made some human errors that resulted in that.

Narrator: Gillin and his colleagues found that the sleepier a person was, the greater the activation in a part of the brain that controls judgment and working memory.

Gillin: This was unexpected to us, but it does suggest that the brain does have compensatory mechanisms and it's not just a simple sleep deprivation effect. It's probably really related to the task that the subject is performing and to a number of other variables, such as how well they're performing or how sleepy they are.

Narrator: For Science Today, I'm Larissa Branin.

 

 

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