Program 710,
  December 4, 2001

 

A. Being Thankful for the Little Things in Life

Narrator: This is Science Today. If you've been feeling grumpy lately, you may be able to turn your mood around by jotting down a daily list of things you're grateful for. Robert Emmons, a professor of psychiatry at the University of California, Davis, says grouchy study participants who did just that became more positive, exercised more and had less health problems.

Emmons: One of the things we're looking at to do next is to actually come up with some way to analyze all of the items subjects listed that they were grateful for. But there seemed to be no limit to the range. Relationships, probably, was the most common theme.

Narrator: But getting people to give thanks for the smaller things in life is not as easy as it sounds.

Emmons: I think it's difficult in general for people - I don't think it's the norm. That's why I think we have to learn to be able to experience and express gratitude. I think the norm is probably to be somewhat dissatisfied with our lot in life and maybe that has some sort of survival value that keeps us motivated. But it does seem to be the case that we need to learn to focus on the things that we do have versus those things we would like to have but we don't.

Narrator: For Science Today, I'm Larissa Branin.

B. A Protein Identified that Regulates One of the Brain's Key Messengers

Narrator: This is Science Today. Researchers at the University of California, San Francisco have identified a protein that plays a key role in releasing glutamate - one of the brain's major neurotransmitters. Dr. Robert Edwards, who led the study, says understanding this process may lead to new targets for treating an array of neuro- degenerative diseases, as well as give scientists better insight about the function of glutamate.

Edwards: The ability of the brain to process information is largely due to glutamate and at the same time, it also contributes to learning and memory and all sorts of other interesting phenomena as well, so it's a very central - if not the central transmitter in the brain.

Narrator: But too much glutamate has been linked to situations including seizures, stroke and Alzheimer's disease. So discovering a protein that regulates this critical brain messenger may lead to better inhibitory drugs.

Edwards: We have some drugs that can inhibit the receptors that glutamate binds to but those drugs, they're either not potent enough or they're not selective enough. So if there's some way in which we can interfere with the release of glutamate - that might have a more potent effect.

Narrator: For Science Today, I'm Larissa Branin.

C. New Evidence about an Old Epidemic

Narrator: This is Science Today. Public health officials have wondered whether another influenza outbreak could reach such deadly proportions as the 1918 epidemic, which killed half a million people. Now, demographer Andrew Noymer of the University of California, Berkeley, has findings suggesting that undetected tuberculosis may have caused much of the mortality in 1918.

Noymer: My results do not show that we are invulnerable to another influenza epidemic. But what they do show is slightly encouraging - that in the United States, where TB death rates are much, much more lower than they were in 1918, that there is a risk factor that has potentially been ignored until now that was TB co-infection.

Narrator: Victims of the 1918 influenza epidemic died of a very severe, secondary bacterial pneumonia, which can be caused by TB infection.

Noymer: There is some plausibility to this story in so far as when people have pulmonary tuberculosis, cavities form in the lungs and they become a breeding ground for bacteria.

Narrator: For Science Today, I'm Larissa Branin.

D. Cigarettes Linked to Ruptured Aneurysms

Narrator: This is Science Today. A link has been found between cigarette smoking and ruptured cerebral aneurysms, which may help doctors decide which patients should undergo early detection for treatment. Dr. Clay Johnston of the University of California, San Francisco says not all aneurysms rupture, but when they do, they're devastating.

Johnston: About fifty percent of people where that's occurred will die from it and then at least half of those that don't die will have some kind f permanent disability from it. Occasionally we'll find these aneurysms before they rupture. So we'll see the dilation in the blood vessel, usually on some kind of imaging study, some kind of scan.

Narrator: Aside from smoking, Johnston says there are several other risk factors for ruptured aneurysms, including age, hypertension and drinking.

Johnston: Family history also, people with family histories tend to be more likely to have one. So there's some predisposition that you're born with, probably and superimposed on that are things you do in your life - your other diseases, like hypertension.

Narrator: For Science Today, I'm Larissa Branin.

E. Another Reason to Continue Flossing …

Narrator: This is Science Today. In case you need another good to reason to floss your teeth, it now appears severe gum disease may play a role in strokes. One way to combat this, is to know who is most susceptible to plaque-causing gum disease. And that's just what UCLA periodontist, Dr. Michael Newman has done with a genetic marker in the form of a finger stick test.

Newman: Up until now, dentists had no way of looking into the crystal ball to determine who was going to be severe and who wasn't. They could sort of, but it wasn't very accurate. Now, with this objective test, dentists and patients can immediately know whether they're at high risk or low risk of getting disease.

Narrator: A gene, which produces anti-inflammatory agents to fight off bacteria, can be detected by this test.

Newman: And having that knowledge allows everybody to focus the most appropriate treatment for that individual's own needs, rather than generalizing by giving either too much treatment or too little.

Narrator: For Science Today, I'm Larissa Branin.

 

 

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