Program 644,
  August 28, 2000

 

A. Scientists Create Radiation Tolerant Materials
B. Questioning the Accountability of Nursing Homes for Poor Staffing
C. A Link Between Post-op Pain and Infection
D. The Rise of Antiobiotic Resistant Bacteria
E. Patients with Kidney Disease Benefit from Anabolic Steroids


A. Scientists Create Radiation-tolerant Materials

Narrator: This is Science Today. One of the limitations in the handling of nuclear waste in this country has been long-term storage. Materials currently encasing radioactive matter degrade with time, making them prone to rupturing or leaching. But the Los Alamos National Laboratory has developed new radiation-tolerant materials that may eventually solve this problem. Kurt Sickafus, a staff scientist, says they worked with a set of materials called crystalline-ceramic oxides.

Sickafus: There are many people that have studied crystalline oxide as waste forms and we believe we've identified a special subset of ceramic oxides, which have very favorable properties for long-term storage.

Narrator: Basically, these materials' atoms shift around to accommodate defects caused by radiation damage.

Sickafus: Our hope is that this will be an important step to get a number of our colleagues in the study of waste forms to take an interest in crystalline waste forms and in particular, the kinds of structures we've proposed looking at in this study.

Narrator: For Science Today, I'm Larissa Branin.


B. Questioning the Accountability of Nursing Homes for Poor Staffing

Narrator: This is Science Today. Nursing home residents in this country receive, on average, a total of three and a half-hours of care per day. And that's not enough, according to a report co-authored by University of California, San Francisco researchers. Charlene Harrington, a professor of social and behavioral sciences, helped conduct a nationwide survey of an expert panel on nursing home care, which recommended better staffing.

Harrington: Some studies have shown if you have more staff, especially RN staff, you have fewer deaths. And we found that facilities have fewer deficiencies when the survey and inspections are done.

Narrator: Harrington says poor staffing is not necessarily due to a lack of funding.

Harrington: There's the issue about are the nursing homes really being accountable and are they really spending the money on what they're supposed to be spending the money on. Only thirty-six percent of every dollar in a nursing home goes to the staff that are giving the direct care, so there's twenty-seven percent going off in administrative cost.

Narrator: For Science Today, I'm Larissa Branin.


C. A Link Between Post-op Pain and Infection

Narrator: This is Science Today. Researchers have discovered an important link between post-operative pain and infection. Dr. Daniel Sessler, a professor of anesthesia at the University of California, San Francisco, discovered that completely controlling pain with medication not only improves patient comfort, but also significantly reduces the risk of infection.

Sessler: Tissue oxygen is known to be the most important factor influencing infection. The reason is that the primary defense against the bacteria that cause surgical infections are killed by neutrophils, which are a type of white blood cells and they depend on oxygen.

Narrator: But pain stimulates the body's protective fight or flight response. This chemical reaction limits the flow of oxygen-rich blood to tissues such as the skin; so more oxygen can go to the brain and other organs necessary in emergencies.

Sessler: However, in post-operative surgical patients, those same responses are not helpful and it's best to use effective pain treatment to block the fight or flight response.

Narrator: For Science Today, I'm Larissa Branin.


D. The Rise of Antibiotic-resistant Bacteria

Narrator: This is Science Today. Federal health officials have recently announced bacteria that cause serious illnesses such as pneumonia and meningitis are becoming increasingly resistant to antibiotics. Dr. Leland Rickman, an expert in infectious disease at the University of California, San Diego, says while this is alarming, it's not surprising.

Rickman: Bacteria from centuries ago have actually been discovered that are resistant to antibiotics even before we discovered them. So, it's nothing new for the bacteria to be able to produce antibiotics in their own right.

Narrator: What is new, is how quickly drug-resistant bacteria are evolving and outsmarting us.

Rickman: In the past, at least we've had the ability to develop new antibiotics to stay one or two steps ahead of some of these microorganisms. But with recent events over the last several years, it's obvious to me and to others that at some point, we are going to lose some antibiotics against certain infections that could potentially bring us back to the pre-antibiotic era.

Narrator: For Science Today, I'm Larissa Branin.


E. Patients with Kidney Disease Benefit from Anabolic Steroids

Narrator: This is Science Today. It's been discovered that patients with kidney disease, who are on dialysis and suffering from malnutrition, benefit from low doses of anabolic steroids, or synthesized testosterone. Dr. Kirsten Johansen, a professor of medicine at the University of California, San Francisco, says these patients often suffer from malnutrition.

Johansen: Malnutrition and low protein mass are the strongest predictors of mortality that we have right now in this group. Our hope was that if we could improve that, perhaps we could improve mortality as well.

Narrator: When patients were given the steroid anabolic steroids for six months, their body mass increased and they reported less fatigue than those given a placebo. Johansen admits these steroids have a controversial air about them, but emphasizes they used much lower doses than those reportedly used by weightlifters.

Johansen: I see this from being very different from use of these compounds by weightlifters. What we're doing here is trying to treat a problem as opposed to taking healthy people and trying to do better.

Narrator: For Science Today, I'm Larissa Branin.

 

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For comments or more information about Science Today, contact Larissa Branin at larissa.branin@ucop.edu