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A.
An Imaging Technique that Helps Detect Alzheimer's
Disease
Narrator:
This is Science Today. An imaging technique that
measures brain chemicals associated with cognitive
damage may provide researchers with an easy, non-invasive
way to distinguish Alzheimer's patients from those
without the disease. Dr. Norbert Schuff, a radiologist
at the University of California, San Francisco,
used an imaging technique similar to MRI called
magnetic resonance spectroscopy, or MRS.
Schuff: We look for markers that are more
specific to indicate neuron loss or neuron dysfunction.
Narrator: Using MRS, the researchers specifically
detected patterns of damage in the brain consistent
with those known to be associated with Alzheimer's
Disease. This could potentially improve the diagnosis
of Alzheimer's and serve as a tool to follow its
progression, but Schuff says the cause of the damage
is not yet fully understood.
Schuff: It's like seeing that your cholesterol
level is out of norm, but you really don't know
why it is so, therefore at the moment, it will not
be possible to use this as a final tool to make
a decision whether someone has Alzheimer's Disease
or not.
Narrator: For Science Today, I'm Larissa
Branin.
B.
Recognizing Binge Eating as a Psychiatric Disorder
Narrator:
This is Science Today. About thirty percent of obese
adults in this country have patterns of binge eating.
Dr. Kim Peter Norman, a psychiatry professor at the
University of California, San Francisco, says although
binge eating is not yet considered an official diagnosis,
it's starting to get lots of attention by primary
care doctors and psychiatrists as an eating disorder.
Norman: The emotional issues that go along
with the eating disorder are very much like what we
see in bulimia nervosa. They'll describe themselves
as filled with self-loathing. They hate their bodies,
they hate their lives, they're depressed, they're
anxious, they believe everybody looks at them with
contempt. And they certainly see themselves that way.
Narrator: Binge eating, which is sometimes
called compulsive eating, is marked by frequent and
repeated eating, usually in private, in which a person
often feels out of control, ashamed or depressed.
Norman:
And for those individuals, emotional factors -
their depression, their anxiety, their self-esteem
- contributes to their obesity. And then we do give
a diagnosis of emotional factors affecting physical
condition obesity. And those individuals do very well
when they're given psychotherapeutic kinds of interventions.
Narrator:For Science Today, I'm Larissa Branin.
C.
Physicists Aim to Create a Primordial State of Matter
Narrator: This is Science Today. Physicists
are using huge ion colliders to reproduce the state
of matter following the Big Bang, the explosion that
gave rise to the universe. Daniel Cebra, a physicist
at the University of California, Davis, took part
in an earlier experiment that recreated hints of this
primordial, plasma-like state. Now, a facility at
the Brookhaven National Laboratory aims to create
large enough chunks of this plasma, so physicists
can better study its properties.
Cebra: Not just to know where the transition
was, but to also know what the compressibility of
the plasma is, the way the plasma behaves in its hot,
dense stage. This will give us an idea of how the
universe behaved at those brief moments - just following
the Big Bang.
Narrator: Cebra says physicists hope to create
definitive evidence of this plasma.
Cebra: By understanding this transition, it
allows us to really understand a lot of where some
of the initial, non-uniformities might have come from.
What was the very early nature of the universe and
those first couple of microseconds?
Narrator: For Science Today, I'm Larissa Branin.
D.
Technological Advances In the Sea
Narrator:
This is Science Today. Thanks to new technology,
researchers have been able to get detailed images
of the Earth's surface below the seafloor. John Orcutt
of the University of California's Scripps Institution
of Oceanography says only recently has it been possible
to actually build instruments that could last long
at the bottom of the ocean.
Orcutt: Instrumentation when I first started
doing this stuff now about twenty-five years ago -
we could leave things on the bottom no more than a
few weeks. We didn't have enough recording capabilities
to record more than a few hours of data on the bottom.
But all that changed, really with the advance in computer
technology available to the consumer.
Narrator: Orcutt was recently in charge of
several instruments placed on the sea floor under
the South Pacific which recorded seismic events for
over a year, giving researchers the first highly detailed
image of the Earth's mantle beneath the oceans.
Orcutt: Oceanography today is at a threshold
where we're going to have the tools to bring lots
of new information and a lot of new discoveries about
the oceans to the table, to research and to what it's
impact on public policy an so on during the coming
decades.
Narrator: For Science Today, I'm Larissa Branin....
E.
A New Frontier in Orthopedics
Narrator:
This is Science Today. Cartilage transplantation is
offering young, active patients with damaged knee
and ankle joints an alternative to total joint replacement.
William Bugbee, a professor of orthopedics at the
University of California, San Diego, says they've
been using this technique, known as fresh osteochondral
allografting, since 1983.
Bugbee:
The reason there's been so much interest in this program
that we've had for so long is that this is sort of
a new frontier in orthopedics - treatment of cartilage
lesions. Now, there are different treatments that
can be used for smaller lesions in the knee, but the
allografting, the actual transplantation is really
the best option for people with bigger problems in
their knee.
Narrator: Because cartilage has no blood supply,
the match is for size only. Once in place, the donor
cartilage knits to the patient's own to form a stable
bond.
Bugbee: We're operating on people in their
teens and twenties. What's going to happen to them
when they're forty or fifty? Is this going to prevent
them from the inevitable arthritis? That's an unanswered
question. But this is the best way to return them
to essentially normal functioning during their active
years and that's what's so important to them.
Narrator: For Science Today, I'm Larissa Branin.
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