Program 467,
  April 8, 1997

 

A. Meteor, Yes -- Death Star, No
B. Protease Inhibitors: A Lifetime Commitment
C. Bad Air May Lead to Bad Skin
D. Back On the Chain Gang?
E. Physician-Assisted Suicide: Don't Ask, Don’t Tell


A. Meteor, Yes -- Death Star, No

Narrator: This is Science Today. Recent discoveries confirm that 65 million years ago, a huge meteor slammed into the earth. But it didn’t kill off the dinosaurs, says paleontologist William Clemens of the University of California, Berkeley. Instead, Clemens points to a changing climate, lots of volcanoes -- and the fact that being big always puts a species at risk.

Clemens: You can see the problem today in trying to maintain populations of elephants or rhinos in Africa. Big animals need lots of room and they need a minimum population size to get together and reproduce, so changes in the topography, the climate, cutting down ranges or breaking them up -- that could be a problem.

Narrator: And whatever killed the dinosaurs, birds and amphibians survived just fine.

Clemens: Yes, you may well have had an impact, it may have had catastrophic effects locally, but to paraphrase a writer in the New York Times who described this discovery as a record of a catastrophic blowtorch of death and destruction -- no, no, that’s way too extreme.

Narrator: For Science Today, I’m Larissa Branin.


B. Protease Inhibitors: A Lifetime Commitment

Kahn: It’s very important to take these medicines very precisely.

Narrator: This is Science Today. New drugs called protease inhibitors, which seem to eliminate the HIV virus from the body, have revolutionized AIDS treatment for those lucky enough to receive them. But Dr. James Kahn of the University of California, San Francisco says there’s a stiff price: besides risking serious side effects, you literally can’t afford to skip a single dose, or else there’s a strong chance the virus will become resistant to the drug.

Kahn: This is not a kind of medicine where you can skip doses, where you can take drug vacations from. You really have to embark on a lifetime commitment of this therapy.

Narrator: And sometimes, says Kahn, the virus becomes resistant anyway.

Kahn: Sometimes the drug’s simply not effective because of a poor match between the virus and the drug, sometimes the drug is given at a low dose or not in the best combination, or sometimes the person’s virus is too hearty.

Narrator: For Science Today, I’m Larissa Branin.


C. Bad Air May Lead to Bad Skin

Narrator: This is Science Today. If you have dry, itchy or scaly skin and live in a big city, chances are ozone, a major air pollutant, may be the reason. University of California, Berkeley researcher Jens (YENS) Theile (TEE-LA) says pollution is already known to cause respiratory problems such as asthma.

Thiele: So we hypothesized that this very strong oxidant, ozone, may also affect the skin. So we started off doing experiments looking at different layers of the skin and looking at anti-oxidants and found that ozone depletes vitamin E and vitamin C only in the outermost layer of the skin.

Narrator: That layer is the barrier between the skin and the rest of the body. In the lab, ozone-exposed mice also suffered damaged lipids, or fatty molecules.

Theile: So, at this point, we have found the first evidence that ozone in addition to UV light may be another environmental source of oxididative stress in the skin.

Narrator: For Science Today, I’m Larissa Branin.


D. Back on the Chain Gang?

Narrator: This is Science Today. A new study on crime policy says legislators should focus more on locking up violent criminals, as opposed to non-violent felons. University of California, Berkeley law professor Edward Rubin led the study.

Rubin: There are alternative ways of punishing non-violent offenders that are more cost-effective, equally effective in terms of punishment and do not create a risk of public safety because essentially, you’re dealing with a relatively non-violent population.

Narrator: Rubin agrees that non-violent offenders such as burglars or drug users should be punished, but says prison alternatives and treatment programs may be more effective and are not as costly.

Rubin: For example, prison typically costs 22 thousand dollars a year. Boot camp programs, which have lower security, but just as effective in terms of stopping people from committing crimes, cost about half that. House arrest with electronic monitoring costs a quarter to a third of prison.

Narrator: For Science Today, I’m Larissa Branin.


E. Physician-Assisted Suicide: Don’t Ask, Don’t Tell

Narrator: This is Science Today. Dr. Donald Abrams of the University of California, San Francisco led a survey of doctors who care for AIDS patients. The subject was physician-assisted suicide, and over half the doctors said they’d helped at least one patient end his or her life. But it’s not something doctors talk about with each other.

Abrams: We asked physicians how often they discussed the issue of physician-assisted suicide with their colleagues, their peers. And among respondents in 1990, the mean response was 3.8 times. And in 1995 it was 2.7 times. So the perception that this is something that we don’t discuss amongst ourselves as health care providers is correct.

Narrator: Abrams says there’s one good reason why that may be so.

Abrams: What we do know is that the Board of Medical Quality Assurance in October of ‘96 issued a brief, if you will, from the Attorney General’s office reminding us all that physician-assisted suicide is tantamount to murder and hence a felony in the state of California.

Narrator: For Science Today, I’m Larissa Branin.

 

 

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For comments or more information about Science Today, contact Larissa Branin at larissa.branin@ucop.edu