Narrator: This is Science Today. New evidence
in cancer development has uncovered a molecular
dialogue between cells that can trigger the onset
of cancer. A team of researchers at the University
of California, San Francisco, including urologic
oncologist Gary Grossfeld, discovered abnormal epithelial
cells from human prostates that were part-way towards
becoming cancerous, were finally pushed towards
cancer by neighboring cells called carcinoma-associated
Grossfeld: We found that when the initiated
cells were grown with normal fibroblasts that they
did not form tumors. But when they were grown with
carcinoma-associated fibroblasts, large tumors formed.
Narrator: Current treatment targets epithelial
cells, which line the surfaces of many organs besides
the prostate, and are the cells from which most
cancers - including breast and colon - arise. But
these findings suggest therapy may instead be directed
towards these carcinoma-associated fibroblasts.
Grossfeld: Our eventual goal is actually
to discover how these cells talk to each other.
If we can figure out how they talk to each other
and what's abnormal, if we can interrupt that, I
think that then we can treat patients and I think
it's very, very exciting.
Narrator: For Science Today, I'm Larissa