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Bicoastal collaboration leads to new model for leukemia

Narrator:       This is Science Today. Almost a decade ago, two former postdocs at Stanford University began exchanging theories about why patients with leukemia stop producing healthy blood cells. Now, even though the University of California, San Francisco's Emmanuelle Passegue is 3,000 miles away from Amy Wagers at Harvard, they have kept up the bicoastal collaboration and have produced a new model for leukemia. Passegue explains it was a natural progression with her former colleague.

Passegue:       She had developed a very nice way to look at change in the bone marrow cavity and so, with my interest in leukemia, her interest in the niche, we really started discussing what kind of approach, technique we could use and we keep this kind of communication going.

Narrator:       They found that cancer stem cells can remodel the environment of the bone marrow to make it inhospitable to healthy cells. This finding could influence the effectiveness of bone marrow transplants. For Science Today, I'm Larissa Branin.