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Microenvironment of the bone marrow cavity


Narrator:       This is Science Today. A team of researchers has discovered new insight into how a leukemia cell can gain a stronghold in bone marrow. Dr. Emmanuelle Passegue, an expert in blood disease at the University of California, San Francisco, says the leukemia cell basically remodels the microenvironment of the bone marrow cavity.

Passegue:       They invade in the bone marrow cavity and form this fibrotic, very pro-inflammatory tissue, which it's kind of an invader in the bone marrow cavity and this invading fibrotic tissue is not good at all for the normal stem cell.

Narrator:       Before, it was thought that normal cells were simple squeezed out of the bone marrow due to overcrowding. So, this new understanding may lead to better treatment strategies for leukemia and other bone marrow diseases.

Passegue:       There is a lot of implication for the finding we have into explaining why now the stem cell of this kind of patient is not working.

Narrator:       For Science Today, I'm Larissa Branin.