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New model of leukemia development

Narrator:       This is Science Today. It turns out that leukemia cells can create a hostile environment in bone marrow and inhibit the development of normal immune cells by essentially kicking them out and encouraging the growth of more cancer cells. Dr. Emmanuelle Passegue, who led the University of California, San Francisco, study, explains that leukemia cells cause other nearby cells to create fibrosis in the bone marrow cavity, which is not a friendly environment. Before this finding, it was thought that the "good" cells were squeezed out due to overcrowding.

Passegue:      That's what this is really putting on the map of the scientific finding. It's not just overcrowding of the bone marrow cavity. It's really changing the deck on a normal cell, making it very bad for them while the transformed cell is fine.

Narrator:       While this is a fundamental discovery, understanding what's going on with these cells may lead to new strategies for fighting cancer.

Passegue:      Maybe if they are put back on the same footing, they might be able to kick back the leukemic cell.

Narrator:       For Science Today, I'm Larissa Branin.