Narrator: This is Science Today. Melanomas are a deadly form of skin cancer that spread to other parts of the body by sending a chemical signal to the sentinel lymph node – a node that's most susceptible to the early spread of the cancer. Dr. Alistair Cochran of the UCLA Jonsson Cancer Center was able to reverse this immune suppression by injecting patients with a compound that stimulates immune activity in the node.
Cochran: So, it looks as though there is some capacity to rescue the lymph nodes. Now, these data have in fact been repeated – the study has been repeated by a number of groups and they have said essentially the same thing using a number of different biologically-active molecules. So, it does look like the potential is there for this kind of biotherapy prior to the removal of the sentinel nodes and we are at this point beginning to make plans for a clinical trial.
Narrator: For Science Today, I'm Larissa Branin.