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Looking to detect treatment-resistant form of prostate cancer


Narrator:       This is Science Today. Researchers at UCLA have developed a new way to detect an aggressive, treatment-resistant form of prostate cancer. Dr. Lilly Wu is one of the researchers who worked to advance this technique, which uses a bioluminescent marker to detect cancer cells. Looking to the future, Wu says that the next step is figuring out how to safely and effectively package this approach for humans.

Wu:               The question is, what is the delivery vehicle? Some people have trepidation about the viral vector. A lot of times it can cause inflammation. So how do you manage to deliver this if you want to give it systemically? One option to overcome this could be treating it with temporary immune suppressive regiment during this process, maybe that could do it? I don't know yet. We haven't gotten to that stage. It will be interesting to test.

Narrator:       Wu says another possibility is using nanoparticles to modify the vector and increase its ability to target cancer cells.

Wu:               So, all of these are interesting approaches that we continue to work on.

Narrator:       For Science Today, I'm Larissa Branin.