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New insight into one of body's most important proteins


Narrator:       This is Science Today. Researchers at the University of California, Berkeley, have uncovered groundbreaking new information about one of the most important protein machines in the human body. Called proteasomes, these machines digest proteins that have become damaged or are no longer necessary. They are critical for regulating many aspects of cellular function.

Martin:          When the cell goes through different cycles, for instance, for division, cell cycles are a very important process that is regulated by the proteasomes.

Narrator:       Biochemist Andreas Martin co-led the study with a team of researchers from the Lawrence Berkeley National Lab. Using a revolutionary new system for protein expression, they have provided the most detailed look ever at the particle that controls proteasome function.

Martin:          This new structure information will help us to come up with new ideas, how to do functional analysis to get a better idea of how proteasome works.

Narrator:       This new information opens up the future possibility of manipulating proteasome activity for the treatment of cancer and other diseases. For Science Today, I'm Larissa Branin.