Narrator:
This is Science Today. Organ transplants
are a risky business. Dr. Flavio Vincenti of the
University of California, San Francisco says that
until recently, the chances of surviving a transplant
were poor, because without the right drugs, new
organs are rejected by the body's immune system.
Vincenti: Up to 1983, we were almost
in the dark ages of drug immuno-therapy. We had
two main drugs. We had very high rejection rates.
Survivals of, for example, kidney transplants were
at best 50 percent at one year.
Narrator: Today, the picture is
much brighter, but researchers are still looking
for better drugs. There was hope a few years ago
with the invention of genetically engineered mouse
antibodies. Unfortunately, our immune systems recognize
a mouse antibody as foreign and reject the drug
itself.
Vincenti: And so these mouse antibodies,
while helpful to some degree, they cannot be used
repeatedly.
Narrator: But now Vincenti and
other doctors are testing a new transplant drug
that's part mouse and part human. The human part
disguises the mouse part, allowing it to work effectively.
For Science Today, I'm Steve Tokar.