Narrator: This is Science Today. Women treated with lumpectomy alone for a non-invasive form of breast cancer known as ductal carcinoma in situ, or DCIS, were more likely to have a recurrence of the disease if their lesion was of a high nuclear grade or if it was a palpable lesion detected during a clinical exam. Karla Kerlikowske of the University of California, San Francisco's Veterans Affairs Medical Center, led the six-year study.
Kerlikowske: I think it can change management in the sense that those that have low nuclear grade or even intermediate nuclear grade, lumpectomy alone is probably sufficient therapy, along with surveillance and monitoring. But if you have high nuclear grade, I would more strongly consider getting adjuvant radiation or maybe taking tamoxifen. So, our goal is to try and treat DCIS less aggressively than in the past and based on some sort of risk factor and knowledge of the disease, as opposed to just aggressively treating everybody as if all these lesions are going to go on and be invasive cancer.
For Science Today, I'm Larissa Branin