Narrator: This is Science Today.
For several reasons, premature babies tend to be
anemic, which means they get lots of transfusions
-- too many, says Dr. Rod Phibbs of the University
of California, San Francisco. In a national study,
Phibbs used a genetically engineered hormone called
erythropoieten to reduce anemia, and thus transfusions,
among preemies.
Phibbs: Well, this is something
that we all make if we're reasonably healthy.
Narrator: In children and adults,
erythropoieten is made in the kidneys. When the
red blood cell count is low, a sensing system there
sends erythropoieten into the bone marrow, where
it stimulates red blood cell production.
Phibbs: The fetus uses erythropoieten
to make red blood cells too, but the system in the
fetus is in the liver. The erythropoieten producing
system and the sensing system in the liver apparently
turns off at birth, and the kidneys should turn
on but they're not quite ready to.
Narrator: In Phibbs's study, injecting
the hormone stimulated the babies' red blood cell
production until their own erythropoieten systems
kicked in -- reducing the need for transfusions.
For Science Today, I'm Steve Tokar.