Researcher Wins Chemistry Nobel
Irwin Rose, a researcher in the UC Irvine College of Medicine, has been named a recipient of the 2004 Nobel Prize in Chemistry. He is the third UCI faculty member to earn the honor.

Rose shares the prize with Aaron Ciechanover and Avram Hershko of the Israel Institute of Technology for their discovery of the major pathway through which cellular building blocks called ubiquitin proteins are regulated by degradation. Cancer and some neurodegenerative diseases are thought to be related to disruptions in this pathway.

The trio’s work helps scientists better understand how ubiquitin modification results in breakdown of unwanted cell proteins; the cell uses similar modifiers to regulate proteins. Their findings play a key role in developing drugs to fight illnesses such as cancer and cystic fibrosis.

Rose, a member of the Department of Physiology and Biophysics, came to UCI in 1997 from the Fox Chase Cancer Center in Philadelphia. 

More information is available online.

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